Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction
نویسندگان
چکیده
منابع مشابه
contribution of setting to the study of characters and the main idea in e. brontes: wuthering heights and t. hardys: return of the native.
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In the direction of reductive condensation of alpha-ketoglutarate and lysine, saccharopine dehydrogenase (N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (lysine-forming) is inhibited by high concentrations of alpha-ketoglutarate and lysine, but not by NADH. NAD+ and saccharopine show no substrate inhibition in the reverse direction. Substrate inhibition by alpha-ketoglutarate and lysine is linear...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2011
ISSN: 0003-9861
DOI: 10.1016/j.abb.2011.07.013